Universidad del Rosario Por: Leticia Domingues Bertuzzi, Patrícia Santos da Silva, Élida Fluck Pereira Neto, Rafael Nicolaidis, Alcyr Alves de Oliveira Jr
There are few animal models of cognitive decline that could be considered as prominent as the cholinergic lesion model of Alzheimer’s disease. Alzheimer’s disease is a neurodegenerative disorder associated with aging with accentuated progressive cognitive impairment. Its multiple complex sequential and interactive neural pathways may lead to the understanding that a single agent intervention might be insufficient to impact the course of this disease. The current pharmacological treatment is palliative and, although it may slow down the disease’s progression, it still cannot offer cure.